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Cannabis compound can help cells
February 19th, 2009 in Medicine & Health / Research
(PhysOrg.com) -- Cannabis has been used recreationally and for medicinal purposes for centuries, yet its 60 plus active components are only partly understood. Now scientists have discovered how a compound in cannabis can help cells to function in our bodies, and aid recovery after a damaging event.
In a paper published in the Journal of Neuroscience, the researchers report on their studies into cannabidiol - a naturally occurring molecule found in cannabis.
Also known as CBD, it is not the constituent that gives the high - that compound is called tetrahydrocannabinol or THC - and so may be more acceptable as a drug treatment.
Both compounds are currently used in a pharmaceutical medicine to help patients relieve pain and other symptoms of Multiple Sclerosis.
Now researchers have discovered how CBD actually works within brain cells.
By interacting with mitochondria - which are the power generators of all cells - it can help maintain normal levels of calcium allowing cells to function properly and providing a greater resistance to damage.
Disturbance of calcium levels has long been associated with a number of brain disorders. So the finding could have implications for the development of new treatments for disorders related to malfunctioning mitochondria.
Dr Bettina Platt, from the University's School of Medical Sciences, said: "Scientists have known for a long time that cannabidiol can help with pain relief but we never really knew how it worked.
"However we have discovered what it actually does at the cellular level.
"We are hoping that our findings can instruct the development of cannabidiol based treatments for disorders related to mitochondrial dysfunction such as Parkinson's disease or Huntington's disease."
Nevertheless, Dr Platt warned that smoking cannabis would not necessarily have the same effect.
"There are different strains of cannabis out there and many no longer contain cannabidiol. In fact, these have been deliberately bred out to enhance the THC content," she said.
"As a result, smoking cannabis would not necessarily have the same beneficial effect, and could even exacerbate neuronal damage."
Provided by University of Aberdeen
source: http://www.physorg.com/news154280470.html
Joycelyn Elders, M.D. wrote in a March 26, 2004 editorial published in the Providence Journal in Rhode Island:
"The evidence is overwhelming that marijuana can relieve certain types of pain, nausea, vomiting and other symptoms caused by such illnesses as multiple sclerosis, cancer and AIDS -- or by the harsh drugs sometimes used to treat them. And it can do so with remarkable safety. Indeed, marijuana is less toxic than many of the drugs that physicians prescribe every day." March 26, 2004
Lester Grinspoon, M.D., Emeritus Professor of Psychiatry at Harvard Medical School, wrote in a March 1, 2007 editorial in the Boston Globe titled "Marijuana as Wonder Drug":
"It is a sad commentary on the state of modern medicine -- and US drug policy -- that we still need 'proof' of something that medicine has known for 5,000 years.
Marijuana is effective at relieving nausea and vomiting, spasticity, appetite loss, certain types of pain, and other debilitating symptoms. And it is extraordinarily safe -- safer than most medicines prescribed every day. If marijuana were a new discovery rather than a well-known substance carrying cultural and political baggage, it would be hailed as a wonder drug." March 1, 2007
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